In 2008, There Were 14,800 Prescription Painkiller Deaths How Prescription Painkiller Deaths Occur Prescription painkillers work by binding to receptors in the brain to decrease the perception of pain. These powerful drugs can create a feeling of euphoria, cause physical dependence, and, in some people, lead to addiction. Prescription painkillers also cause sedation and slow… Continue reading For Every Prescription Drug Death In The United States There Are :